Cancer, Medulloblastoma - StatPearls - NCBI Bookshelf
نویسنده
چکیده
Introduction While leukemias are the most common type of malignancy to afflict the pediatric population, brain tumors are the most common solid tumors in this age group. Medulloblastoma is the most common malignant brain tumor in children, accounting for 20% of all pediatric brain tumors. It is categorized as a primitive neuroectodermal tumor of the cerebellum. While mortality within the first two years of diagnosis can be approximately 10% to 15%, cure rates can reach as high as 60% with current therapeutic modalities. Surgical resection, preceded and/or followed by radiation and chemotherapy, is the mainstay of therapy, with five-year survival rates of between 50% to 90%; this wide range is multifactorial, owing in part to age at diagnosis, the presence of metastases at diagnosis, and a histologic variant of Medulloblastoma. Regardless of long-term survival, treatment-related neurologic, cognitive, and endocrinologic sequelae remain a debilitating concern and an impetus for the search for novel therapeutics.
منابع مشابه
NCBI Bookshelf: books and documents in life sciences and health care
Bookshelf (http://www.ncbi.nlm.nih.gov/books/) is a full-text electronic literature resource of books and documents in life sciences and health care at the National Center for Biotechnology Information (NCBI). Created in 1999 with a single book as an encyclopedic reference for resources such as PubMed and GenBank, it has grown to its current size of >1300 titles. Unlike other NCBI databases, su...
متن کاملBacterial and Viral Infections -- Essentials of Glycobiology -- NCBI Bookshelf
Infectious diseases remain a major cause of death, disability, and social and economic disorder for millions of people throughout the world. Poverty, poor access to health care, human migration, emerging disease agents, and antibiotic resistance all contribute to the expanding impact of infectious diseases. Prevention and treatment strategies for infectious diseases derive from a thorough under...
متن کاملEntrez Help
Entrez is NCBI’s primary text search and retrieval system that integrates the PubMed database of biomedical literature with 39 other literature and molecular databases including DNA and protein sequence, structure, gene, genome, genetic variation and gene expression. This document is an overview of the Entrez databases, with general information on searching and displaying data. More detailed he...
متن کاملInsights into cerebellar development and medulloblastoma. - PubMed - NCBI
Cerebellar development is an extensive process that begins during early embryonic stages and persists more than one year after birth in human. Therefore, the cerebellum is susceptible to acquire various developmental abnormalities leading to numerous diseases such as medulloblastoma, the most common pediatric malignant brain tumor. One third of the patients with medulloblastoma are incurable an...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2017